![Pirates to open 2022 season at home against Cardinals, play interleague games vs. AL East](https://www.masslive.com/resizer/eKCN3hHuOhhVNrhJkd26Bz0jjrk=/1280x0/smart/cloudfront-us-east-1.images.arcpublishing.com/advancelocal/C7RZFPGDYJERXCXBOCANS5T7QI.png)
Boston Red Sox 2023 schedule includes trips to Wrigley Field, San
![Pirates to open 2022 season at home against Cardinals, play interleague games vs. AL East](https://cbsaustin.com/resources/media/b3dace96-98dd-48fa-8654-c8ae88ad7448-full36x25_AP21216049525745.jpg?1628130501222)
MLB season starts March 31, again with every team scheduled
![Pirates to open 2022 season at home against Cardinals, play interleague games vs. AL East](https://fox2now.com/wp-content/uploads/sites/14/2021/04/GettyImages-1232186816.jpg?strip=1)
MLB releases 2022 St. Louis Cardinals schedule
![Pirates to open 2022 season at home against Cardinals, play interleague games vs. AL East](https://9b16f79ca967fd0708d1-2713572fef44aa49ec323e813b06d2d9.ssl.cf2.rackcdn.com/1140x_a10-7_cTC/Cardinals-Pirates-Baseball-32-1664937965.jpg)
Pirates lose 100th game of the season in extra-inning defeat to
![Pirates to open 2022 season at home against Cardinals, play interleague games vs. AL East](https://www.dkpittsburghsports.com/img/Pirates/Live%20File%20Photos/Live%20File%20West%20GR-1600x900.jpg)
Pirates to open 2022 season at home against Cardinals
![Pirates to open 2022 season at home against Cardinals, play interleague games vs. AL East](https://img.mlbstatic.com/mlb-images/image/private/t_16x9/t_w1024/mlb/aewq5li8intjiwm0jl7n)
Best Interleague moments in MLB history
![Pirates to open 2022 season at home against Cardinals, play interleague games vs. AL East](https://images2.minutemediacdn.com/image/upload/c_fill,w_1440,ar_16:9,f_auto,q_auto,g_auto/shape/cover/sport/6fd422c95e4a286da68704b05adc7ef22f622db2516feff67f88d5e5024ea32b.jpg)
Why increasing MLB interleague play is counterproductive
![Pirates to open 2022 season at home against Cardinals, play interleague games vs. AL East](https://wehco.media.clients.ellingtoncms.com/imports/adg/photos/202067990_202067990-da6153ae763a4e37ae24319931de13cd_t800.jpg?90232451fbcadccc64a17de7521d859a8f88077d)
Sweeping up: Hot Cards run streak to 7 games
![Pirates to open 2022 season at home against Cardinals, play interleague games vs. AL East](https://i.abcnewsfe.com/a/71afd015-0476-4e80-adeb-75bebfb2b074/wirestory_7fdda31a1d8311457d040d2bed526bb3_16x9.jpg?w=992)
Analysis: It looks like it'll take all 162 games to decide MLB's